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OTS964 HCl

OTS964 HCl 1338545-07-5
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Chemical Information
Product name:OTS964 HCl Purity:98% min
CAS NO:1338545-07-5 Solubility:DMSO : ≥ 83.33 mg/mL (194.26 mM)
Molecular Formula:C23H25ClN2O2S Package:Package according to customer requirements
Molecular Weight:428.975 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration of the free compound induced hematopoietic adverse reactions (leukocytopenia associated with thrombocytosis), the drug delivered in a liposomal formulation effectively caused complete regression of transplanted tumors without showing any adverse reactions in mice.
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