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Product :

YKL-5-124

YKL-5-124 1957203-01-8
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Chemical Information
Product name:YKL-5-124 Purity:98.0% min
CAS NO:1957203-01-8 Solubility:DMSO : ≥ 100 mg/mL (158.82 mM)
Molecular Formula:C28H33N7O3 Package:Package according to customer requirements
Molecular Weight:515.607 Storage:Store at -20℃
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Remarks

YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status.

 

 

 

CDK Inhibitors Related Products:

Palbociclib HCl; SNS-032; PF-00562271 Besylate; A-674563; NU6027; 1-NM-PP1; Trilaciclib; OTS964 HCl; Indisulam; Apcin; Palbociclib

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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