CC-4047 Pomalidomide

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Chemical Information

Product name：CC-4047 Pomalidomide	Purity：98% min
CAS NO：19171-19-8	Solubility：DMSO : ≥ 100 mg/mL (365.98 mM)
Molecular Formula：C₁₃H₁₁N₃O₄	Package：Package according to customer requirements
Molecular Weight：273.244	Storage：Store at -20℃

Quality control

COA

Remarks

Pomalidomide, also known as CC4047, is an orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). Pomalidomide was approved on February 8, 2013 as a treatment for relapsed and refractory multiple myeloma.

E3 Ligase Inhibitors Related Products:

Lenalidomide; Serdemetan; TAME; RITA; Apcin; GMB-475; Avadomide; BC-1258

References

[1]. Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7.

[2]. Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11(16):5984-92.

[3]. Schafer PH, et al. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J Pharmacol Exp Ther. 2003 Jun;305(3):1222-32.