RITA NSC 652287

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Chemical Information

Product name：RITA NSC 652287	Purity：98% min
CAS NO：213261-59-7	Solubility：DMSO : ≥ 100 mg/mL (342.03 mM)
Molecular Formula：C₁₄H₁₂O₃S₂	Package：Package according to customer requirements
Molecular Weight：292.373	Storage：Store at -20℃

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Remarks

RITA, also known as NSC 652287, is an inducer of both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. RITA is also an inhibitor of MDM2-p53 interaction by targeting p53 and induces apoptosis in tumor cells.

E3 Ligase Inhibitors Related Products:

Lenalidomide; Pomalidomide; Serdemetan; TAME; Apcin; GMB-475; Avadomide; BC-1258

References

[1]. Issaeva N, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med. 2004 Dec;10(12):1321-8. Epub 2004 Nov 21.

[2]. Nieves-Neira W, et al. DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Mol Pharmacol. 1999 Sep;56(3):478-84.