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Product :

GMB-475

GMB-475 GMB-475
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Chemical Information
Product name:GMB-475 Purity:98% min
CAS NO:GMB-475 Solubility:DMSO : 250 mg/mL (290.05 mM)
Molecular Formula:C43H46F3N7O7S Package:Package according to customer requirements.
Molecular Weight:861.93 Storage:-20 ℃
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Remarks

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein. GMB-475 reduced viability and increased apoptosis in primary CML CD34+ cells, with no effect on healthy CD34+ cells at identical concentrations.

 

 

 

E3 Ligase Inhibitors Related Products:

Lenalidomide; Pomalidomide; Serdemetan; TAME; RITA; Apcin; Avadomide; BC-1258

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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