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Product :

Cyclopamine

Cyclopamine 4449-51-8
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Chemical Information
Product name:Cyclopamine Purity:98%min
CAS NO:4449-51-8 Solubility:DMSO: 0.32 mg/mL
Molecular Formula:C27H41NO2 Package:Package according to customer requirements
Molecular Weight:411.62 Storage:Store at -20℃
Quality control
COA
Remarks

Cyclopamine, also known as 11-deoxojervine, is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho.

 

 

 

Hedgehog/Smoothened Inhibitors Related Products:

Sonidegib; PF-5274857; GANT61; Glasdegib; Taladegib; BMS-833923; Vismodegib; Purmorphamine 

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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