GANT61

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Chemical Information

Product name：GANT61	Purity：98% min
CAS NO：500579-04-4	Solubility：DMSO : 17.6 mg/mL (40.97 mM)
Molecular Formula：C₂₇H₃₅N₅	Package：Package according to customer requirements
Molecular Weight：429.600	Storage：Store at -20℃

Quality control

COA

Remarks

GANT61 (NSC 136476) is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM in GLI1 expressing HEK293T cell, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. GANT61 induces apoptosis and activates protective autophagy in LX-2 cells.

Hedgehog/Smoothened Inhibitors Related Products:

Cyclopamine; Sonidegib; PF-5274857; Glasdegib; Taladegib; BMS-833923; Vismodegib; Purmorphamine

References

[1]. Mazumdar T, et al. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011 Feb 1;71(3):1092-102

[2]. Fu J, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. 2013 Mar 1;330(1):22-32.

[3]. Wickstrom M, et al. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer. 2013 Apr 1;132(7):1516-24.