Purmorphamine

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Chemical Information

Product name：Purmorphamine	Purity：98% min
CAS NO：483367-10-8	Solubility：DMSO : 50 mg/mL (96.04 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₃₁H₃₂N₆O₂	Package：Package according to customer requirements
Molecular Weight：520.625	Storage：Store at -20℃

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Remarks

Purmorphamine is a Hedgehog agonist, which activates the Hedgehog pathway by targeting Smoothened. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth.

Hedgehog/Smoothened Inhibitors Related Products:

Cyclopamine; Sonidegib; PF-5274857; GANT61; Glasdegib; Taladegib; BMS-833923; Vismodegib

References

[1]. F. Faghihia, et al. The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Biomedicine & Pharmacotherapy. 2013, 67(1): 31-38.

[2]. Gu D, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66.