GDC-0449 Vismodegib

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Chemical Information

Product name：GDC-0449 Vismodegib	Purity：98% min
CAS NO：879085-55-9	Solubility：DMSO : ≥ 50 mg/mL (118.68 mM)
Molecular Formula：C₁₉H₁₄Cl₂N₂O₃S	Package：Package according to customer requirements
Molecular Weight：421.297	Storage：Store at -20℃

Quality control

COA

Remarks

Vismodegib, also known as GDC-0449 or RG3616, is a hedgehog antagonist, is also a n orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling.

Hedgehog/Smoothened Inhibitors Related Products:

Cyclopamine; Sonidegib; PF-5274857; GANT61; Glasdegib; Taladegib; BMS-833923; Purmorphamine

References

[1]. Scales SJ, et al. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009, 30(6), 303-312.

[2]. Zhang Y, et al. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia. 2009, 11(1), 96-101.

[3]. Tian F, et al. The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. Anticancer Res. 2012, 32(1), 89-94.