BMS-345541

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Chemical Information

Product name：BMS-345541	Purity：98% min
CAS NO：445430-58-0	Solubility：DMSO : 10 mg/mL (39.17 mM)
Molecular Formula：C₁₄H₁₇N₅	Package：Package according to customer requirements
Molecular Weight：255.318	Storage：Store at -20℃

Quality control

COA

Remarks

BMS-345541 free base is a selective inhibitor of IKK-1 and IKK-2 with IC50 value of 4μM and 0.3μM, respectively. IKK is also known as nuclear factor kappa-B kinase subunit inhibitor and involves in cytokine-activated intracellular signaling pathways.

IκB/IKK Inhibitors Related Products:

Resveratrol; BAY 11-7082; IKK-16; TPCA-1; BMS-345541 HCl; SC-514; LY2409881 trihydrochloride; IMD-0354; Bardoxolone methyl; TBK1; WS6; WS3 ; MRT67307

References

[1]. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456.

[2]. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960.