BMS-345541 HCl

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Chemical Information

Product name：BMS-345541 HCl	Purity：98% min
CAS NO：547757-23-3	Solubility：DMSO : 20 mg/mL (68.54 mM)
Molecular Formula：C₁₄H₁₈ClN₅	Package：Package according to customer requirements
Molecular Weight：291.779	Storage：Store at -20℃

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Remarks

BMS 345541 is a selective allosteric inhibitor of IKK (IC50 values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). It attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. BMS 345541 also suppresses joint destruction in a mouse model of arthritis.

BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.

IκB/IKK Inhibitors Related Products:

Resveratrol; BAY 11-7082; IKK-16; TPCA-1; BMS-345541; SC-514; LY2409881 trihydrochloride; IMD-0354; Bardoxolone methyl; TBK1; WS6; WS3 ; MRT67307

References

[1]. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456.

[2]. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960.