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Product :

BML-277

BML-277 516480-79-8
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Chemical Information
Product name:BML-277 Purity:98% min
CAS NO:516480-79-8 Solubility:DMSO : ≥ 55 mg/mL (151.18 mM)
Molecular Formula:C20H14ClN3O2 Package:Package according to customer requirements
Molecular Weight:363.797 Storage:Store at -20℃
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Remarks

BML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. ML-277 has IC50 = 15 nM; Ki = 37 nM. ML-277 shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively).

 

 

Chk Inhibitors Related Prodcuts:

AZD7762 HCl; Rabusertib (LY2603618); MK-8776; CHIR-124; PF-477736; PD0166285; AZD7762

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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