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LY2603618 Rabusertib IC-83

LY2603618 Rabusertib IC-83 911222-45-2
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Chemical Information
Product name:LY2603618 Rabusertib IC-83 Purity:98% min
CAS NO:911222-45-2 Solubility:DMSO : 29.5 mg/mL (67.61 mM)
Molecular Formula:C18H22BrN5O3 Package:Package according to customer requirements
Molecular Weight:436.303 Storage:Store at -20℃
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Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk2 is overexpressed by a variety of cancer cell types.

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