SB-742457 Intepirdine

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Chemical Information

Product name：SB-742457 Intepirdine	Purity：98% min
CAS NO：607742-69-8	Solubility：DMSO : 50 mg/mL (141.47 mM)
Molecular Formula：C₁₉H₁₉N₃O₂S	Package：Package according to customer requirements.
Molecular Weight：353.438	Storage：Store at -20℃

Quality control

COA

Remarks

Intepirdine, also known as SB-742457, also known as RVT-101, is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing effects. It was under development by GlaxoSmithKline for the treatment of Alzheimer's disease and demonstrated some preliminary efficacy in phase II clinical trials. SB742457 can reverse age-related declines in delayed non-match-to-sample performance (DNMS). SB742457 shows increasing pro-cognitive effects in patients with AD.

5-HT Receptor Inhibitors Related Products:

RS-127445; Asenapine Maleate; WAY-100635 Maleate; WAY-100635 maleate salt; Vortioxetine; Vortioxetine hydrobromide; Blonanserin; Sertraline HCl; Lamotrigine; Azasetron hydrochloride; Iloperidone; Lasmiditan

References

[1]. Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63(5):890-7.

[2]. Codony X, Vela JM, Ramírez MJ. 5-HT(6) receptor and cognition. Curr Opin Pharmacol. 2011 Feb;11(1):94-100.