WAY-100635 maleate salt

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Chemical Information

Product name：WAY-100635 maleate salt	Purity：98% min
CAS NO：634908-75-1	Solubility：DMSO : ≥ 34 mg/mL (63.12 mM)
Molecular Formula：C₂₉H₃₈N₄O₆	Package：Package according to customer requirements
Molecular Weight：538.635	Storage：Store at -20℃

Quality control

Remarks

WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 ± 0.12 nM for 5-HT. IC50 Value: 0.95 nM Target: 5-HT Receptor in vitro: WAY 100635 has an IC50 of 1.35 nM and is > 100-fold selective for the 5-HT1A site relative to a range of other CNS receptors. The Bmax of [3H]WAY 100635 specific binding is consistently 50-60% greater than that of the agonist radioligand, [3H]8-OH-DPAT. Mn2+, but not guanine nucleotides, inhibits [3H]WAY 100635-specific binding.

Synonyms:

N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt;

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate;

5-HT Receptor Inhibitors Related Products:

RS-127445; Asenapine Maleate; WAY-100635 Maleate; Vortioxetine; Vortioxetine hydrobromide; Blonanserin; Intepirdine; Sertraline HCl; Lamotrigine; Azasetron hydrochloride ; Iloperidone

References

[1]. Choi JY, Kim CH, Jeon TJ, Kim BS, Yi CH, Woo KS, Seo YB, Han SJ, Kim KM, Yi DI, Lee M, Kim DG, Kim JY, Lee KC, Choi TH, An G, Ryu YH.Effective microPET imaging of brain 5-HT(1A) receptors in rats with [(18) F]MeFWAY by suppression of radioligand defluorin

[2]. Mannucci C, Navarra M, Calzavara E, Caputi AP, Calapai G.Serotonin involvement in Rhodiola rosea attenuation of nicotine withdrawal signs in rats.Phytomedicine. 2012 Aug 23.

[3]. Katsidoni V, Anagnostou I, Panagis G.Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT(1A) receptors in the dorsal raphe nucleus.Addict Biol. 2012 Aug 2.