Proteinase inhibitor E-64

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Proteinase inhibitor E-64	Purity：98% min
CAS NO：66701-25-5	Solubility：DMSO : ≥ 22 mg/mL (61.55 mM)
Molecular Formula：C₁₅H₂₇N₅O₅	Package：Package according to customer requirements
Molecular Weight：357.405	Storage：Store at 2-8ºC

Quality control

COA

Remarks

E-64 is a potent, and irreversible inhibitor of cysteine proteases with IC50 values for inhibiting cathepsins K, S, and L, in vitro, are 1.4, 4.1, and 2.5 nM, respectively. E-64 improves the preimplantation development of bovine somatic cell nuclear transfer embryos.

Properties:
Appearance & Physical State: white solid
Density: 1.44 g/cm3
Melting Point: 182ºC
Refractive Index: 1.617

Cysteine Protease Inhibitors Related Prodcuts:

Odanacatib; PMSF; Balicatib; Pepstatin A; Leupeptin hemisulfate; Aloxistatin

References

[1]. Matsumoto K, et al. Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. Biopolymers. 1999;51(1):99-107.

[2]. Wadhawan M, et al. Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite. PLoS One. 2014 Mar 25;9(3):e93161.