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Aloxistatin(E64D)

Aloxistatin(E64D) 88321-09-9
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Chemical Information
Product name:Aloxistatin(E64D) Purity:98%min
CAS NO:88321-09-9 Solubility:Soluble in DMSO
Molecular Formula:C17H30N2O5 Package:Packaging according to customer requirements
Molecular Weight:342.43 Storage:Store at -20℃
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Remarks

Aloxistatin (E64d) is a broad-spectrum cell-permeable cysteine protease inhibitor.

Inhibition of protease-resistant prion protein (PrP-res) accumulation in ScNB cells by cysteine protease inhibitor Aloxistatin (E64d) with IC50 of 0.5±0.11 μM. For the cell surface PrP-sen detection, PrP-sen is immunoprecipitated from media treated with phosphatidylinositol-specific phospholipase C (PIPLC) to release pulse-35S-labeled PrP-sen from the cell surface. Aloxistatin is maintained at 15 μM, respectively, in the labeling media of all but the control cells [1]. Aloxistatin (E64d) (which specifically blocks cysteine proteases, but not serine proteases such as granzymes) is able to completely block turnover of the CatL substrate Z-Phe-Arg-aminomethylcoumarin, when pre-incubated with NK-92 or YT 5 cells[2]. Aloxistatin (E64d) is a broad-spectrum cell-permeable inhibitor of cysteine proteases[3].

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