Mestranol (INN, USAN, BAN, JAN) (brand names Devocin, Ovastol, Tranel), also known as ethinyl estradiol methyl ether (EEME), is a synthetic, steroidal estrogen that has been widely used medically. It was employed as the estrogen component in many of the first oral contraceptives, such as mestranol/noretynodrel (brand names Enovid, Enavid), and is still in use today. It was also a component of Ortho-Novin, Femigen, and Norbiogest. In addition to its use as an oral contraceptive, mestranol has been used as a component of hormone replacement therapy.
Mestranol is the 3-methyl ether of ethinyl estradiol, and is a biologically inactive prodrug of ethinyl estradiol to which it is demethylated in the liver with a conversion efficiency of 70% (50µg of mestranol is pharmacokinetically bioequivalent to 35µg of ethinyl estradiol).
Estrogen/progestogen Receptor Inhibitors Related Products:
Quinestrol; Lynestrenol; AZD9496; DY131; Mifepristone; GSK5182; Levonorgestrel; Medroxyprogesterone Acetate; Progesterone; Estriol; Estrone; Bazedoxifene Acetate; Endoxifen HCl; Altrenogest; Zearalenone; Etonogestrel; Dienogest; Gestodene