Endoxifen HCl

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Chemical Information

Product name：Endoxifen HCl	Purity：98% min
CAS NO：1032008-74-4	Solubility：DMSO : ≥ 40 mg/mL (97.57 mM)
Molecular Formula：C₂₅H₂₈ClNO₂	Package：Package according to customer requirements
Molecular Weight：409.948	Storage：Store at -20℃

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Remarks

Z-Endoxifen HCl is an estrogen receptor alpha (ERalpha) ligand, potent antiestrogen, and metabolite of tamoxifen. Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because it bypasses potential drug resistance mechanisms attributable to patient variability in the expression of the hepatic microsomal enzyme CYP2D6.

Estrogen/progestogen Receptor Inhibitors Related Products:

Fulvestrant; Raloxifene hydrochloride; Lasofoxifene Tartrate; Brilanestrant; Tamoxifen; Tamoxifen citrate; Dienogest; Drospirenone; Ulipristal acetate; Megestrol Acetate; Pregnenolone; Estriol; Estrone; Bazedoxifene Acetate; Ospemifene ; AZD9496

References

[1]. Chae YJ, et al. Endoxifen, the active metabolite of tamoxifen, inhibits cloned hERG potassium channels. Eur J Pharmacol. 2015 Apr 5;752:1-7.

[2]. Wu X, et al. Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 Mar 10;13(2):R27.