Ulipristal acetate

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Chemical Information

Product name：Ulipristal acetate	Purity：98% min
CAS NO：126784-99-4	Solubility：DMSO : 33.33 mg/mL (70.08 mM)
Molecular Formula：C₃₀H₃₇NO₄	Package：Package according to customer requirements
Molecular Weight：475.619	Storage：Store at -20℃

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Remarks

Ulipristal acetate, also known as CDB-2914, is a selective progesterone receptor modulator (SPRM) approved for contraception, and for uterine fibroid. As a SPRM, ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to the glucocorticoid receptor, but is only a weak antiglucocorticoid relative to mifepristone, and has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.

Estrogen/progestogen Receptor Inhibitors Related Products:

Fulvestrant; Raloxifene hydrochloride; Lasofoxifene Tartrate; Brilanestrant; Tamoxifen; Tamoxifen citrate; Dienogest; Drospirenone; Megestrol Acetate; Pregnenolone; Estriol; Estrone; Bazedoxifene Acetate; Endoxifen HCl; Ospemifene ; AZD9496

References

[1]. Attardi BJ, et al. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol. 2004 Ma

[2]. Ciarmela P, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014 Sep;21(9):1120-5.

[3]. Munuce MJ, et al. Effects of ulipristal acetate on sperm DNA fragmentation during in vitro incubation. Eur J Contracept Reprod Health Care. 2013 Oct;18(5):355-63.