AZD9496

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Chemical Information

Product name：AZD9496	Purity：98% min
CAS NO：1639042-08-2	Solubility：DMSO : ≥ 104.5 mg/mL (236.17 mM)
Molecular Formula：C₂₅H₂₅F₃N₂O₂	Package：Package according to customer requirements
Molecular Weight：442.473	Storage：Store at -20℃

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Remarks

AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist. AZD9496 can induce ERα degradation in breast cancer cell lines at picomolar concentrations. AZD9496 is curently under clinical trials. AZD9496 may be useful for the treatment of ER+ breast cancer.

Estrogen/progestogen Receptor Inhibitors Related Products:

Fulvestrant; Raloxifene hydrochloride; Lasofoxifene Tartrate; Brilanestrant; Tamoxifen; Tamoxifen citrate; Dienogest; Drospirenone; Ulipristal acetate; Megestrol Acetate; Pregnenolone; Estriol; Estrone; Bazedoxifene Acetate; Endoxifen HCl; Ospemifene; Desogestrel

References

[1]. Weir HM, et al. AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models. Cancer Res. 2016 Jun 1;76(11):3307-18.

[2]. De Savi C, et al. Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. J Med Chem. 2015 Oct 22;58(20):8128-40.