Megestrol Acetate

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Chemical Information

Product name：Megestrol Acetate	Purity：98% min
CAS NO：595-33-5	Solubility：DMSO: 11.53 mg/mL (Need ultrasonic)
Molecular Formula：C₂₄H₃₂O₄	Package：Package according to customer requirements.
Molecular Weight：384.508	Storage：Store at -20℃

Quality control

COA

Remarks

Megestrol acetate is the acetate ester of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes.

Properties:
Appearance & Physical State: Crystalline Solid
Density: 1.15g/cm3
Melting Point: 214ºC
Boiling Point: 507.1ºC at 760mmHg
Flash Point: 218.5ºC
Refractive Index: 11 ° (C=2, CHCl3)

Estrogen/progestogen Receptor Inhibitors Related Products:

Fulvestrant; Raloxifene hydrochloride; Lasofoxifene Tartrate; Brilanestrant; Tamoxifen; Tamoxifen citrate; Dienogest; Drospirenone; Ulipristal acetate; Pregnenolone; Estriol; Estrone; Bazedoxifene Acetate; Endoxifen HCl; Ospemifene ; AZD9496

References

[1]. Neumann, F., The physiological action of progesterone and the pharmacological effects of progestogens--a short review. Postgrad Med J, 1978. 54 Suppl 2: p. 11-24.

[2]. Argiles, J.M., A. Anguera, and B. Stemmler, A new look at an old drug for the treatment of cancer cachexia: megestrol acetate. Clin Nutr, 2013. 32(3): p. 319-24.