GSK5182

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Chemical Information

Product name：GSK5182	Purity：98% min
CAS NO：877387-37-6	Solubility：Soluble in DMSO
Molecular Formula：C₂₇H₃₁NO₃	Package：Package according to customer requirements
Molecular Weight：417.54	Storage：-20 ℃

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Remarks

GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma (HCC).

Synonyms:

Benzenebutanol, δ-[[4-[2-(dimethylamino)ethoxy]phenyl](4-hydroxyphenyl)methylene]-, (δZ)-;

(δZ)-δ-[[4-[2-(Dimethylamino)ethoxy]phenyl](4-hydroxyphenyl)methylene]benzenebutanol;

Estrogen/progestogen Receptor Inhibitors Related Products:

Quinestrol; Lynestrenol; Mestranol; AZD9496; DY131; Mifepristone; Levonorgestrel; Medroxyprogesterone Acetate; Progesterone; Estriol; Estrone; Bazedoxifene Acetate; Endoxifen HCl; Altrenogest; Zearalenone; Etonogestrel; Dienogest; Gestodene; Allylestrenol

References

1: Joo J, Wu Z, Lee B, Shon JC, Lee T, Lee IK, Sim T, Kim KH, Kim ND, Kim SH, Liu KH. In vitro metabolism of an estrogen-related receptor γ modulator, GSK5182, by human liver microsomes and recombinant cytochrome P450s. Biopharm Drug Dispos. 2015 Apr;36(3):163-73. doi: 10.1002/bdd.1929. PubMed PMID: 25451157.