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VX-222 Lomibuvir

VX-222 Lomibuvir 1026785-59-0
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Chemical Information
Product name:VX-222 Lomibuvir Purity:98% min
CAS NO:1026785-59-0 Solubility:DMSO : ≥ 32 mg/mL (71.81 mM)
Molecular Formula:C25H35NO4S Package:Packaging according to customer requirements
Molecular Weight:445.615 Storage:Store at -20℃
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Remarks
Lomibuvir, also known as VX-222, VCH-222 and VX22, is an nonnucleoside NS5B polymerase inhibitor. VX-222 inhibits the 1b/Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX-222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1 HCV.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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