TMC435 Simeprevir

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Chemical Information

Product name：TMC435 Simeprevir	Purity：98% min
CAS NO：923604-59-5	Solubility：DMSO : 14.29 mg/mL (19.05 mM)
Molecular Formula：C₃₈H₄₇N₅O₇S₂	Package：Package according to customer requirements
Molecular Weight：749.939	Storage：Store at -20℃

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Remarks

Simeprevir, also known as TMC43, is a drug for the treatment and cure of hepatitis C. In the United States, simeprevir is approved by the Food and Drug Administration for use in combination with peginterferon-alfa and ribavirin for hepatitis C and hepatitis B. Simeprevir has been approved in Japan for the treatment of chronic hepatitis C infection, genotype 1.

HCV Protease Inhibitors Related Prodcuts:

Daclatasvir; Daclatasvir hcl; Telaprevir; Lomibuvir; Danoprevir; Paritaprevir; Paritaprevir dihydrate; Grazoprevir; Elbasvir; Ombitasvir; Velpatasvir; Ledipasvir; Boceprevir

References

[1]. Raboisson P, et al. Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8.

[2]. Lin TI, et al. In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor.Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85. Epub 2009 Jan 26.