Boceprevir

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Chemical Information

Product name：Boceprevir	Purity：98% min
CAS NO：394730-60-0	Solubility：DMSO : 16.67 mg/mL (32.08 mM)
Molecular Formula：C₂₇H₄₅N₅O₅	Package：Package according to customer requirements
Molecular Weight：519.677	Storage：Store at -20℃

Quality control

COA

Remarks

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a Ki of 14 nM in both enzyme assay and an EC90 of 350 nM in cell-based replicon assay. Boceprevir inhibits SARS-CoV-2 3CLpro activity.

HCV Protease Inhibitors Related Prodcuts:

Daclatasvir; Daclatasvir hcl; Telaprevir; Lomibuvir; Danoprevir; Paritaprevir; Paritaprevir dihydrate; Grazoprevir; Elbasvir; Ombitasvir; Simeprevir; Velpatasvir; Ledipasvir

References

[1]. Njoroge FG, et al. Challenges in modern drug discovery: a case study of boceprevir, an HCV protease inhibitor for the treatment of hepatitis C virus infection. Acc Chem Res. 2008 Jan;41(1):50-9.

[2]. Yao M, et al. Conditional Inducible Triple-Transgenic Mouse Model for Rapid Real-Time Detection of HCV NS3/4A ProteaseActivity. PLoS One. 2016 Mar 4;11(3):e0150894.