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ITMN-191 Danoprevir

ITMN-191 Danoprevir 850876-88-9
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Chemical Information
Product name:ITMN-191 Danoprevir Purity:98% min
CAS NO:850876-88-9 Solubility:10 mM in DMSO
Molecular Formula:C35H46FN5O9S Package:Package according to customer requirements
Molecular Weight:731.831 Storage:Store at -20℃
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Remarks
Danoprevir, also known as ITMN-191 and RG-7227, is under development by InterMune Inc and Roche Holding AG, is a promising, potent NS3/4A protease inhibitor for the oral treatment of HCV infection. Preclinical data demonstrated that danoprevir binds with high affinity and dissociates slowly from the HCV NS3 protease, allowing high liver drug exposure with only modest plasma drug exposure. A phase Ib, 'IFN-free' clinical trial demonstrated that danoprevir, combined with the HCV polymerase inhibitor RG-7128 (Pharmasset Inc/Roche Holding AG), was effective in reducing HCV-RNA levels in a large proportion of treatment-naïve patients with HCV infection and in approximately half of previously non-responsive patients with HCV-1 infection, without resistance or safety concerns.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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