SU5614

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Chemical Information

Product name：SU5614	Purity：98% min
CAS NO：1055412-47-9	Solubility：DMSO: 10 mg/mL (36.66 mM)
Molecular Formula：C₁₅H₁₃ClN₂O	Package：Package according to customer requirements
Molecular Weight：272.730	Storage：Store at -20℃

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Remarks

SU5614 is a potent and selective FLT3 inhibitor. SU5614 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells. SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.

FLT3 Inhibitors Related Products:

Crenolanib; Dovitinib; FLX925; Quizartinib; Brigatinib; Pacritinib; Fedratinib; TG101209; SGI-1776; Tandutinib; Tamatinib ; G-749

References

1: Arseni N, Ahmed F, Hiddemann W, Buske C, Feuring-Buske M. Effects of the protein tyrosine kinase inhibitor, SU5614, on leukemic and normal stem cells. Haematologica. 2005 Nov;90(11):1577-8. PubMed PMID: 16266907.

2: Aleskog A, HÃ¶glund M, Pettersson J, Hermansson M, Larsson R, Lindhagen E. In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia. Leuk Res. 2005 Sep;29(9):1079-81. Epub 2005 Apr 15. PubMed PMID: 16038735.