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AC220 Quizartinib

AC220 Quizartinib 950769-58-1
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Chemical Information
Product name:AC220 Quizartinib Purity:98% min
CAS NO:950769-58-1 Solubility:DMSO : ≥ 33 mg/mL (58.86 mM)
Molecular Formula:C29H32N6O4S Package:Package according to customer requirements
Molecular Weight:560.667 Storage:Store at -20℃
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Remarks

Quizartinib, also know as AC220 and AC010220, is an orally available FLT3 / STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.

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