Tandutinib (MLN518)

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Chemical Information

Product name：Tandutinib (MLN518)	Purity：98% min
CAS NO：387867-13-2	Solubility：DMSO : 50 mg/mL (88.86 mM; Need ultrasonic)
Molecular Formula：C₃₁H₄₂N₆O₄	Package：Package according to customer requirements
Molecular Weight：562.703	Storage：Store at -20℃

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Remarks

Tandutinib, also known as MLN 518, is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.

Properties:

Appearance & Physical State: White Solid

Density: 1.213 g/cm3

Boiling Point: 769.5ºC at 760 mmHg

Melting Point: 177-178ºC

Flash Point: 419.2ºC

Refractive Index: 1.61

FLT3 Inhibitors Related Products:

Crenolanib; Dovitinib; FLX925; Quizartinib; Brigatinib; Pacritinib; Fedratinib; TG101209; SGI-1776; SU5614; Tamatinib ; G-749

References

[1]. Kelly LM, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 2002, 1(5), 421-432.

[2]. Griswold IJ, et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood, 2004, 104(9), 2912-2918.

[3]. Schittenhelm MM, et al. The FLT3 inhibitor tandutinib (formerly MLN518) has sequence-independent synergistic effects with cytarabine and daunorubicin. Cell Cycle, 2009, 8(16), 2621-2630.