FLX925 AMG 925

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Chemical Information

Product name：FLX925 AMG 925	Purity：98% min
CAS NO：1401033-86-0	Solubility：DMSO : < 1 mg/mL
Molecular Formula：C₂₆H₂₉N₇O₂	Package：Package according to customer requirements
Molecular Weight：471.554	Storage：Store at -20℃

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Remarks

FLX925, also known as AMG-925, is a potent and selective type 1 inhibitor of FLT3 that retains its cellular potency against clinically relevant secondary resistance mutations in FLT3 occurring with quizartinib or sorafenib treatment (FLX925 IC50: MOLM13ITD, 15 nM; MOLM13ITD/D835, 28 nM; MV4-11ITD, 16 nM; MV4-11ITD/D835, 19 nM; MV4-11ITD/N841, 16 nM; MV4-11ITD/F691, 73 nM).

FLT3 Inhibitors Related Products:

Crenolanib; Dovitinib; Quizartinib; Brigatinib; Pacritinib; Fedratinib; TG101209; SGI-1776; Tandutinib; SU5614; Tamatinib; G-749

References

[1]. Keegan K, et al. Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. Mol Cancer Ther. 2014 Apr;13(4):880-9.