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Ruxolitinib phosphate

Ruxolitinib phosphate 1092939-17-7
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Chemical Information
Product name:Ruxolitinib phosphate Purity:98% min
CAS NO:1092939-17-7 Solubility:DMSO: ≥ 31 mg/mL; H2O: 5.4 mg/mL
Molecular Formula:C17H21N6O4P Package:Package according to customer requirements
Molecular Weight:404.36 Storage:Store at -20℃
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Remarks

Ruxolitinib, also known as INC424 and INCB18424 or INCB018424, is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

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