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AZD1480

AZD1480 935666-88-9
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Chemical Information
Product name:AZD1480 Purity:98% min
CAS NO:935666-88-9 Solubility:DMSO : 50 mg/mL (143.36 mM)
Molecular Formula:C14H14ClFN8 Package:Package according to customer requirements
Molecular Weight:348.766 Storage:Store at -20℃
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Remarks

AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.

 

 

 

 

JAK Inhibitors Related Products:

Ruxolitinib; Ruxolitinib phosphate; Tofacitinib; Momelotinib; Gandotinib; AZ960; Pacritinib; XL019; Upadacitinib; Decernotinib; Filgotinib; GLPG0634 analogue; FLLL32; AG-490 (Tyrphostin B42); NSC-42834; Itacitinib; Go6976; Baricitinib; Oclacitinib; Oclacitinib maleate; WP1066

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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