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Ruxolitinib

Ruxolitinib 941678-49-5
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Chemical Information
Product name:Ruxolitinib Purity:98% min
CAS NO:941678-49-5 Solubility:DMSO : ≥ 36 mg/mL (117.50 mM)
Molecular Formula:C17H18N6 Package:Package according to customer requirements
Molecular Weight:306.365 Storage:Store at -20℃
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Remarks
Ruxolitinib potently and selectively inhibits JAK2V617F-mediated signaling and proliferation, markedly increases apoptosis in a dose dependent manner, and at 64 nM results in a doubling of cells with depolarized mitochondria in Ba/F3 cells. Ruxolitinib demonstrates remarkable potency against erythroid colony formation with IC50 of 67 nM, and inhibits proliferating of erythroid progenitors from normal donors and polycythemia vera patients with IC50 values of 407 nM and 223 nM, respectively.
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