AG-490 Tyrphostin B42

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Chemical Information

Product name：AG-490 Tyrphostin B42	Purity：98% min
CAS NO：133550-30-8	Solubility：DMSO : ≥ 57 mg/mL (193.68 mM)
Molecular Formula：C₁₇H₁₄N₂O₃	Package：Package according to customer requirements
Molecular Weight：294.305	Storage：Store at -20℃

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Remarks

Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death.

JAK Inhibitors Related Products:

Ruxolitinib; Ruxolitinib phosphate; Tofacitinib; AZD1480; Momelotinib; Gandotinib; AZ960; Pacritinib; XL019; Upadacitinib; Decernotinib; Filgotinib; GLPG0634 analogue; FLLL32; NSC-42834; Itacitinib; Go6976; Baricitinib; Oclacitinib; Oclacitinib maleate ; WP1066

References

[1]. Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3(4):459-63

[2]. Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162(7):3897-904.