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AZD8055 fumarate

AZD8055 fumarate  1201799-05-4
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Chemical Information
Product name:AZD8055 fumarate Purity:98% min
CAS NO:1201799-05-4 Solubility:Soluble in DMSO
Molecular Formula:C29H35N5O8 Package:Package according to customer requirements
Molecular Weight:581.617 Storage:Store at -20℃
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AZD-8055 is an inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD8055 inhibits the serine/threonine kinase activity of mTOR, resulting in decreased expression of mRNAs necessary for cell cycle progression, which may induce cell cycle arrest and tumor cell apoptosis. mTOR phosphorylates transcription factors, such as S6K1 and 4E-BP1, which stimulate protein synthesis and regulate cell growth, proliferation, motility, and survival.



Related Prodcuts:

Tacrolimus; AZD8055; OSI-027; Vistusertib; Zotarolimus; XL388; INK 128; PP121; Desmethyl-VS-5584; AZD-8055


1. Liu M, Gu P, Guo W, Fan X. C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor. Tumour Biol. 2016 Aug;37(8):11039-48. doi: 10.1007/s13277-015-4598-1. Epub 2016 Feb 20. PMID: 26897748.

2. Jin ZZ, Wang W, Fang DL, Jin YJ. mTOR inhibition sensitizes ONC201-induced anti-colorectal cancer cell activity. Biochem Biophys Res Commun. 2016 Sep 30;478(4):1515-20. doi: 10.1016/j.bbrc.2016.08.126. Epub 2016 Aug 24. PMID: 27565731.

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