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Product :

XL388

XL388 1251156-08-7
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Chemical Information
Product name:XL388 Purity:98% min
CAS NO:1251156-08-7 Solubility:DMSO : 50 mg/mL (109.77 mM)
Molecular Formula:C23H22FN3O4S Package:Package according to customer requirements
Molecular Weight:455.502 Storage:Store at -20℃
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Remarks

XL388 is a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.

 

 

 

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Tacrolimus; AZD8055; AZD8055 fumarate; OSI-027; Vistusertib; Zotarolimus; INK 128; PP121; Desmethyl-VS-5584; AZD-8055

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