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INK-128 Sapanisertib

INK-128 Sapanisertib 1224844-38-5
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Chemical Information
Product name:INK-128 Sapanisertib Purity:98% min
CAS NO:1224844-38-5 Solubility:DMSO : ≥ 83.3 mg/mL (269.29 mM)
Molecular Formula:C15H15N7O Package:Package according to customer requirements
Molecular Weight:309.326 Storage:Store at -20℃
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Sapanisertib, also known as TAK-228, MLN0128 and INK128, is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.




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Tacrolimus; AZD8055; AZD8055 fumarate; OSI-027; Vistusertib; Zotarolimus; XL388; PP121; Desmethyl-VS-5584; AZD-8055

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