PS-210

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Chemical Information

Product name：PS-210	Purity：98% min
CAS NO：1221962-86-2	Solubility：DMSO : 100 mg/mL (262.94 mM; Need ultrasonic)
Molecular Formula：C₁₉H₁₅F₃O₅	Package：Package according to customer requirements
Molecular Weight：380.315	Storage：-20 ℃

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Remarks

PS-210 is an activator of phosphoinositide-dependent protein kinase 1 (PDK1) that increases its thermal stability.1,2 It is selective for PDK-1 over a panel of 120 kinases at 10 µM.1 PS-210 (2 µM) increases the activity of wild-type PDK1 but not PDK1 with a mutation in the PIF-binding pocket.

PDK Inhibitors Related Prodcuts:

BX795; PHT-427; GSK2334470; PS-48 ; OSU-03012 (AR-12)

References

1.Busschots, K., Lopez-Garcia, L.A., Lammi, C., et al.Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking siteChem. Biol.19(9)1152-1163(2012) 2.Wilhem, A., Lopez-Garcia, L.A., Busschots, K., et al.2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: Development and prodrug conceptJ. Med. Chem.55(22)9817-9830(2012)