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PHT-427 1191951-57-1
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Chemical Information
Product name:PHT-427 Purity:98% min
CAS NO:1191951-57-1 Solubility:10 mM in DMSO
Molecular Formula:C20H31N3O2S2 Package:Package according to customer requirements
Molecular Weight:409.609 Storage:Store at -20℃
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PHT-427 is an AKT inhibitor that inhibits AKT and PDPK1 at low micromolar concentrations in numerous cancer cell lines and exhibits good oral anti-tumor activity in mouse xenograft models. PHT-427 reduces the phosphorylation of AKT and PDPK1. Following the administration of a single oral dose of PHT-427 to mice bearing BxPC-3 human pancreatic tumor xenografts, PHT-427 inhibited the phosphorylation of both Akt and PDPK1 as well as downstream targets maximally at 8–12 h after administration corresponding to its peak plasma concentration, with PDPK1 inhibition extending to 24 hr.
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