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KRX-0401 Perifosine

KRX-0401 Perifosine  157716-52-4
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Chemical Information
Product name:KRX-0401 Perifosine Purity:98% min
CAS NO:157716-52-4 Solubility:H2O : ≥ 153.33 mg/mL (332.13 mM)
Molecular Formula:C25H52NO4P Package:Package according to customer requirements
Molecular Weight:461.658 Storage:Store at -20℃
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Remarks

Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine.


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