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ONC-201 TIC10

ONC-201 TIC10 1616632-77-9
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Chemical Information
Product name:ONC-201 TIC10 Purity:98% min
CAS NO:1616632-77-9 Solubility:DMSO : 33.33 mg/mL (86.24 mM)
Molecular Formula:C24H26N4O Package:Package according to customer requirements
Molecular Weight:386.489 Storage:Store at -20℃
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Remarks

ONC-201, also known as TIC10 and imipridone, is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. TIC10 induces a sustained up-regulation of TRAIL in tumors and normal cells that may contribute to the demonstrable antitumor activity of TIC10. TIC10 inactivates kinases Akt and extracellular signal-regulated kinase (ERK), leading to the translocation of Foxo3a into the nucleus, where it binds to the TRAIL promoter to up-regulate gene transcription. TIC10 is an efficacious antitumor therapeutic agent that acts on tumor cells and their microenvironment to enhance the concentrations of the endogenous tumor suppressor TRAIL.

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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