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AT13148

AT13148 1056901-62-2
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Chemical Information
Product name:AT13148 Purity:98% min
CAS NO:1056901-62-2 Solubility:DMSO : 50 mg/mL (159.35 mM)
Molecular Formula:C17H18Cl3N3O Package:Package according to customer requirements
Molecular Weight:386.703 Storage:Store at -20℃
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Remarks

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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