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PF-4708671

PF-4708671 1255517-76-0
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Chemical Information
Product name:PF-4708671 Purity:98% min
CAS NO:1255517-76-0 Solubility:10 mM in DMSO
Molecular Formula:C19H21F3N6 Package:Package according to customer requirements
Molecular Weight:390.405 Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
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Remarks

PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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