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BI-D1870

BI-D1870 501437-28-1
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Chemical Information
Product name:BI-D1870 Purity:98% min
CAS NO:501437-28-1 Solubility:DMSO : 100 mg/mL (255.48 mM)
Molecular Formula:C19H23F2N5O2 Package:Package according to customer requirements
Molecular Weight:391.415 Storage:Store at -20℃
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Remarks

BI-D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM. BI-D1870 exhibited a dose-responsive antiproliferative effect on OSCC cells with relative sparing of normal human oral keratinocytes. The compound inhibited the downstream RSK target YB-1 and caused apoptosis. In addition, BI-D1870 also induced G2/M arrest by modulating the expression of p21 and other cell cycle regulators. BI-D1870 may be of useful in oral squamous cell carcinoma therapy.

 

 

 

S6 Kinase Inhibitors Related Prodcuts:

AT7867; H-89; H-89 2HCl; Staurosporine; Pluripotin; LY-2584702; AT13148; Bosutinib; PF-4708671

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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