Staurosporine, also known as antibiotic AM-2282 or STS, is a potent, non-selective inhibitor of protein kinases, including protein kinase C with promising anti-cancer activity. Staurosporine is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive. The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity.
PKC Inhibitors Related Products:
GSK690693; Valrubicin; ML-7 HCl; Midostaurin; Go6976; TAS-301; Fasudil; Fasudil (HA-1077) HCl; HA-1100 Hydroxyfasudil; Enzastaurin; PF-4708671