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AD-32 Valrubicin

AD-32 Valrubicin 56124-62-0
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Chemical Information
Product name:AD-32 Valrubicin Purity:98% min
CAS NO:56124-62-0 Solubility: 10 mM in DMSO
Molecular Formula:C34H36F3NO13 Package:Package according to customer requirements
Molecular Weight:723.644 Storage:Store at -20℃
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| MSDS
Remarks
Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration.
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