ML-7 HCl

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Chemical Information

Product name：ML-7 HCl	Purity：98% min
CAS NO：110448-33-4	Solubility：DMSO : ≥ 43 mg/mL (94.98 mM)
Molecular Formula：C₁₅H₁₈ClIN₂O₂S	Package：Package according to customer requirements
Molecular Weight：452.738	Storage：Store at -20℃

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Remarks

ML-7 is a MLCK inhibitor. ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 µM. ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line. ML-7 inhibits exocytosis of superoxide-producing intracellular compartments in human neutrophils stimulated with phorbol myristate acetate in a myosin light chain kinase-independent manner.

PKC Inhibitors Related Products:

GSK690693; Staurosporine; Valrubicin; Midostaurin; Go6976; TAS-301; Fasudil; Fasudil (HA-1077) HCl; HA-1100 Hydroxyfasudil ; Enzastaurin

References

[1]. Shi J, et al. Myosin light chain kinase-independent inhibition by ML-9 of murine TRPC6 channels expressed in HEK293cells. Br J Pharmacol. 2007 Sep;152(1):122-31.

[2]. Yu J, et al. Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation. Int J Med Sci. 2015 Sep 4;12(9):727-36.