Enzastaurin LY317615

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Chemical Information

Product name：Enzastaurin LY317615	Purity：98% min
CAS NO：170364-57-5	Solubility：DMSO : 8.33 mg/mL (16.16 mM)
Molecular Formula：C₃₂H₂₉N₅O₂	Package：Package according to customer requirements
Molecular Weight：515.605	Storage：Store at -20℃

Quality control

COA

Remarks

Enzastaurin is a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.

PKC Inhibitors Related Products:

GSK690693; Staurosporine; Valrubicin; ML-7 HCl; Midostaurin; Go6976; TAS-301; Fasudil; Fasudil (HA-1077) HCl; HA-1100 Hydroxyfasudil

References

[1]. Rovedo MA, et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol, 2011, 131(7), 1442-1449.

[2]. Podar K, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood, 2007, 109(4), 1669-1677.