HA-1100 Hydroxyfasudil

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Chemical Information

Product name：HA-1100 Hydroxyfasudil	Purity：98% min
CAS NO：105628-72-6	Solubility：DMSO : ≥ 31 mg/mL (100.86 mM)
Molecular Formula：C₁₄H₁₇N₃O₃S	Package：Package according to customer requirements
Molecular Weight：307.368	Storage：Store at -20℃

Quality control

Remarks

Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively.

PKC Inhibitors Related Products:

GSK690693; Staurosporine; Valrubicin; ML-7 HCl; Midostaurin; Go6976; TAS-301; Fasudil; Fasudil (HA-1077) HCl; Enzastaurin

References

[1]. Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1.

[2]. Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7.